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Contraindicated (one)pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with potent CYP3A4 inducers; these medications reduce publicity to vandetanib by as much as 40%.Too fast administration may well cause respiratory despair, laryngospasm, apnea

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